Restylane Refyne and Defyne have been FDA-approved since December 2016 and have already shown us amazing results! These two new fillers, offered at Cosmetic Laser Dermatology in San Diego, CA, use an innovative proprietary technology called XpresHAn (pronounced “expression”) that allows them the flexibility to move with your every expression while still performing their job of lifting and smoothing. “Natural” results have reached a new level with these dermal fillers!


Wrinkle Treatment Experts and Skin Care Specialists

*Disclaimer: Results vary from patient to patient. Results are not guaranteed.

Refyne and Defyne are often talked about together, but they are separate products best for separate uses. Refyne is a softer, more malleable filler that is great for fine lines and subtle lip augmentation. Defyne is a thicker, firmer filler perfect for injecting deep into the skin to provide structure and lift to the midface. Defyne is better for those patients who have deeper lines or want more dramatic volume in the lips.

We often use Refyne and Defyne together for comprehensive results. Combination injectable treatments allow us to fully customize a plan for the face and to inject the best product into the best area for unparalleled results. If a patient is concerned about sagging cheeks, nasolabial folds, perioral lines, and thinning lips, we can create amazing results using Defyne to lift the cheeks and reduce the appearance of nasolabial folds and Refyne to gently smooth lip lines and add a touch of natural volume to the lips. To learn more about dermal fillers, visit

Schedule a Consultation Today

Our San Diego dermatologists utilize Restylane Refyne and Defyne to help treat a variety of conditions from fine lines and wrinkles all the way to loss of facial volume! Contact us today to set up a consultation and find out how dermal fillers can rejuvenate your appearance.

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The information available on this website is provided for informational purposes only. This information is not intended to replace a medical consultation where a physician’s judgment may advise you about specific disorders, conditions and/or treatment options. We hope the information will be useful for you to become more educated about your health care decisions.

*Free in-person consultations are available with Drs. Butterwick, Groff, Wu, Boen, and Leysin Fletcher, PA-C. General Dermatology consultations are subject to a fee. Virtual consultations are subject to a fee that may be applied towards treatment. Promotions are not available with Dr Goldman.