Restylane® Refyne® and Defyne®
Erase laugh lines and wrinkles without freezing your face. Restylane Refyne and Defyne use XpresHAn Technology™ to flex with your expressions for results that look and feel naturally you.
Enhance Your Skin with Restylane Refyne and Defyne
With Restylane Refyne and Defyne, you can:
What Are Restylane Refyne and Defyne?
Restylane Refyne and Restylane Defyne are next-generation hyaluronic acid dermal fillers developed with XpresHAn Technology™, which allows the gel to move naturally with your facial expressions. These fillers are ideal for treating nasolabial folds (smile lines) and marionette lines while maintaining a natural look so you still look like yourself, just refreshed.
Restylane Refyne and Defyne — Enhancements That Elevate Your Confidence
Natural-Looking Flexibility
Formulated with XpresHAn Technology™ to move with your facial expressions, keeping your results subtle and natural.
Customized for Depth and Support
Restylane Refyne targets moderate lines and folds, while Restylane Defyne treats deeper wrinkles and areas needing more structural support.
Instant Smoothing Effect
Visibly softens fine lines and wrinkles for a smoother, more youthful complexion that looks instantly refreshed.
Hyaluronic Acid Hydration
HA attracts moisture, keeping skin plump, smooth, and hydrated from within.
Comfortable and Safe
Includes lidocaine for a more comfortable treatment experience with minimal downtime or discomfort.
Clinically Proven Longevity
Results can typically last up to 12 months or longer, depending on the treatment area and individual metabolism.
Hear From Our Happy Patients
5/5 STARS
I trust Farzaneh Momeni completely with my skin. She is by far the best clinical aesthetician I’ve ever known. My skin has improved dramatically since I began monthly facials with her. Her treatments are 100% results-driven so if this is what you seek, look no further. Also, the entire Team at West Dermatology are top-notch. They’re always friendly, professional, & helpful, & greet everyone with a smile. 10 Stars all around!
My new regular cosmetic dermatology office. Dr Zubair is amazing and really patient with me. He has helped me over the last year with keloid scar removal, jaw Botox, and full facial acne scar treatment (ultra clear). The office is clean and the nursing/medical assistant staff is accommodating on all levels. I will always recommend this office and Dr Zubair to friends and family.
Most professional and most impressive! The service from the physicians to office staff is superb!
I live in Orange County and drove all the way out to see Dr. Wu because a friend of mine referred him (she had amazing results from her face and neck procedure). Dr. Wu is truly an artist! He made me feel extremely comfortable during my procedure. I was anxious when I got there, but he (and his staff) have such great energy and are so very kind and gentle that you can't help but feel at ease! The office was immaculate and they adhered to covid rules (sanitizing, temp checks, masks). This is my go-to place from now on and Dr. Wu is my go-to guy! Can't wait to see my final results! Thank you Phyllis (pre-op) for being so wonderful and informative! You were so very helpful and kind! I'll definitely be back!
Leysin and the entire team at Cosmetic Laser Dermatology are fantastic. They are professional, caring and communicative. The laser treatment was comfortable, efficient and effective! I highly recommend this practice. I definitely will come back and recommend her and Cosmetic Laser Dermatology to my family and friends.
Dr. Goldman is amazing! I came here for my permanent eyeliner removal (which is not offered anywhere near me), and they are completely removed in just one session. They use a special contact lens to protect your eyes from the laser, and there are no damages to my eyelashes. The healing was also nice and smooth. They have everything you need. I live almost 3 hours away, but it was totally worth the trip. For anyone who is looking to remove their permanent makeup, this is the right place to go :)-
Dr. Butterwick is fantastic, all of her team as well. They make sure your experience is pleasant and painless as possible. My tattoo removal and my injectables look amazing. I highly recommend her for any skin treatment.
Cosmetic Laser Dermatology was recommended to me by my dermatologist. He recommended Dr. Monica Boen. I'm so glad I took his recommendation. Everyone here at Cosmetic Laser Dermatology was super nice and friendly. Very welcoming. I came here for hair removal treatment. I did 4 sessions with Dr. Boen. Dr. Boen made me feel so comfortable and at ease when I talked to her. She explained everything before she did my treatment. I loved that. She was really easy to talk to. I definitely will come back and recommend her and Cosmetic Laser Dermatology to my family and friends.
This office is awesome. My visit today was with Dr. Groff. His bed side manner is so fun and welcoming. He understood my concerns and recommended a treatment plan that I feel was reasonable. I love his staff! They take there time to make sure you understand the treatment and after care. Everyone in the office, from the front desk to the nurses in the back, are so friendly and beautiful. They are very prompt and I trust my care with CLD. I can't wait for my next visit. See you guys in a few weeks!
"Dr. Sabrina Fabi is genius! Her technique is unlike anyone, her eye is precise, and her kindness and caring manner comes from the depth of her soul. She's simply brilliant! It's no wonder people travel the country just to be treated by her."
I wish I could give them 10 stars! I had such an awesome experience for my first visit and I am referring everyone I know to this office. From the super friendly staff to the state of the art procedures, they are the cream of the crop.
“I came to participate in a research study. All of the Doctors and staff at C.L. Dermatology are very professional, warm and friendly. All our my needs were anticipated and the hospitality of this office is like a five star hotel.”
Why You'll Love Us
At Cosmetic Laser Dermatology, our board-certified dermatologists and physician assistant are recognized experts in injectable artistry and facial anatomy. With participation in clinical research for the Restylane family of fillers, we know how to deliver refined, natural-looking results that maintain your unique expression. Our team uses Restylane Refyne and Defyne alongside advanced techniques and combination treatments, such as Take10, Take5, and 3xFacial, to smooth lines, boost collagen, elastic fiber, and hyaluronic acid production, and restore youthful contours without looking overdone.
What to Expect from Restylane Refyne and Defyne
Get a Personalized Treatment Plan
Your dermatologist will analyze your facial structure and movement to determine whether Refyne, Defyne, or a combination of both is best suited for your lines and folds.
Experience Expert Injection Techniques
Every procedure is performed by our board-certified dermatologists and physician assistant, ensuring safe, precise placement and balanced, natural outcomes.
See Immediate, Natural Results
You’ll notice visible smoothing and softening right after treatment, with full results developing as the filler integrates into your skin over 1–2 weeks. Individual results may vary.
Enjoy Long-Lasting Confidence
Both Restylane Refyne and Defyne deliver results that can typically last up to 12 months or longer. Maintenance sessions help sustain smooth, youthful contours while supporting skin hydration. Individual results may vary.
Our Renowned Dermatologists
We are proud to share that Dr. Goldman, Dr. Butterwick, Dr. Groff, Dr. Fabi, & Dr. Boen have once again been recognized as Castle Connolly Top Doctors in 2026!
Cosmetic Laser Dermatology has been voted Best Cosmetic Dermatology Practice in San Diego Magazine’s 2026 “Best of San Diego” readers’ poll!
Dr. William Groff was voted Best Cosmetic Dermatologist, Best Cosmetic Surgeon, and Best Dermatologist for 4 consecutive years by the San Diego Reader Best Poll.
Dr. Mitchel Goldman was voted #1 Cosmetic Dermatologist in America by Newsweek
Dr. William Groff was voted Best Cosmetic Dermatologist and Best Cosmetic Surgeon for 9 consecutive years by the San Diego U-T Best Readers Poll.
Drs. Goldman, Butterwick, and Fabi made the top 8 in Newsweek’s Best Cosmetic Dermatologists in America for the last two years in a row
Voted in the top 10% of Realself Doctors by achieving high patient satisfaction and getting favorable feedback on Q&A
Dr. William Groff was voted Best Dermatologist for 10 consecutive years and Best Cosmetic Surgeon for 9 consecutive years by the La Jolla Light Best Readers Poll.
Drs. Goldman, Butterwick, Groff, Fabi, and Boen were named Castle Connolly Top Doctors in 2025, making us one of the Top 3 Practices in California with the most Castle Connolly Top Doctors in Dermatology.
Dr. Boen has been recognized as a Top Doctor in 2023 and 2024 by San Diego County Medical Society.
Dr. Butterwick is a distinguished facial cosmetic surgeon certified by the American Board of Facial
Cosmetic Surgery (ABFCS).
In 2026, Mitchel P. Goldman, MD, FAAD, received the Richard E. Fitzpatrick, MD Award from Masters of Aesthetics in recognition of his contributions to cosmetic dermatology and laser medicine. The honor reflects his longstanding leadership in research, physician education, and advancing aesthetic treatment.
Sabrina Fabi, MD has been named a finalist for Pioneer of the Year – Healthcare with San Diego Magazine’s Celebrating Women 2026
Frequently Asked Questions About Restylane Refyne and Defyne
When comparing Restylane Refyne vs Defyne, both are made with XpresHAn Technology™ but differ in firmness and flexibility. Refyne is designed for moderate lines and more natural movement, while Defyne offers stronger support for deeper folds and more noticeable contouring.
Both fillers use hyaluronic acid (HA) to smooth wrinkles and restore lost volume while maintaining flexibility. The HA binds to water molecules, adding hydration and fullness while supporting natural facial expression.
These fillers are ideal for treating nasolabial folds (smile lines), marionette lines, and lower-face wrinkles. They can also subtly enhance chin and jawline contours when a soft, natural look is desired.
Results are immediate and continue to improve as the filler settles into the skin over the next few days, revealing a smoother, more youthful appearance. Individual results may vary.
Results can typically last up to 12 months or longer, depending on your skin, lifestyle, and the area treated. Touch-up sessions help maintain optimal results year-round. Individual results may vary.
Yes—thanks to XpresHAn Technology™, both fillers integrate seamlessly with facial movements for a soft, flexible finish that looks natural whether you’re smiling, laughing, or speaking
Absolutely. Our dermatologists often pair these fillers with neuromodulators like Botox Cosmetic, Dysport, Daxxify, Xeomin, and Jeuveau, skin tightening using Ulthera, Thermage or Sofwave, or our Take10 rejuvenation protocol to enhance definition and boost collagen, elastic fiber, and hyaluronic acid production for more comprehensive facial rejuvenation.
Yes. Both fillers are FDA-approved and clinically proven to be safe and effective when administered by trained professionals. Mild swelling, bruising, or tenderness may occur but typically resolves within a few days.
Our team includes national filler trainers and researchers who helped pioneer techniques for achieving natural, long-lasting results. At Cosmetic Laser Dermatology, every treatment is tailored to your facial dynamics to ensure you look refreshed, not overfilled.
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