Deep facial wrinkles can be challenging to treat, but options are available. The best treatment for these stubborn creases is often a combination of non-surgical procedures customized to your precise needs and goals.
What Causes Deep Facial Wrinkles?
Wrinkles are a natural part of the aging process. Creases that appear in the lower half of the face are often the result of collagen depletion and are known as static wrinkles. Collagen is an essential protein found in the dermis that gives our skin a smooth, supple appearance. Over time, our bodies produce less collagen, leading to skin laxity and the formation of wrinkles.
Certain factors can accelerate collagen depletion and the formation of deep facial wrinkles, including genetics, sun exposure, smoking, and environmental pollutants. UV light speeds up the aging process by breaking down collagen and elastin, which keep skin tight. Once the damage occurs, deep facial wrinkle treatment is the only way to reverse the lines and creases.
Neuromodulators for Deep Lines and Wrinkles
Neuromodulators are most effective for treating dynamic wrinkles. These lines develop when you smile, squint, or frown. At first, the lines are only visible when you make a facial expression, but they can become a permanent fixture on the face over time. They commonly form between the eyebrows (deep frown lines), in the outer corners of the eyes (crow’s feet), or across the forehead.
Neuromodulators effectively relax facial muscles, smoothing away the lines they create. They offer results that last 3-4 months, but patients can maintain their improvement indefinitely with a regular treatment schedule.
Botox, Dysport, Xeomin, and Daxxify for Deep Facial Wrinkles
Cosmetic Laser Dermatology, located in San Diego, boasts a team of board-certified dermatologists who are also national Botox trainers. We use Botox, Dysport, Xeomin, Jeuveau, and the newest neuromodulator, Daxxify, which offers the longest-lasting results. We understand how to leverage each product’s unique attributes to best suit our patients’ individual needs.
Our staff has been actively involved in research studies for neuromodulators and continues to conduct clinical trials at our fully equipped research center. We are one of the first in the area to offer Daxxify treatments to our patients.

Dermal Fillers For Deep Lines and Wrinkles
Dermal fillers are an effective treatment for static wrinkles because they restore lost volume and plump up the skin. Filler involves injecting a gel-like substance, typically made of hyaluronic acid, into the targeted area. This substance fills creases from the inside out, creating a smooth, youthful appearance.
Dermal fillers can be administered in a matter of minutes. Results are visible immediately, and the effects can last several months, depending on the type of filler used and the individual’s metabolism. These injectables work well on nasolabial folds, smile lines, and marionette lines. They can also be placed in the tear troughs to refresh the eyes and around the mouth to address fine lines and plump up the lips.
How Juvéderm and Restylane Can Help Fill Deep Wrinkles

Juvedérm® is a line of dermal fillers that uses hyaluronic acid to smooth out wrinkles and restore lost volume in various areas of the face. Specific products include:
- Juvedérm® XC
- Juvedérm® Voluma
- Juvedérm® Vollure
- Juvedérm® Volbella
- Juvederm Volux
Each formulation is designed for a different treatment area. While Juvedérm XC and Voluma tend to work best on deep wrinkles, our dermatologists will determine the best product for you based on your precise needs and goals.
Restylane® is another line of dermal fillers containing hyaluronic acid as the active ingredient. These injectable gels are specially designed to fill in deep wrinkles and fine lines, enhance facial contours, and add volume to areas such as the cheeks and lips. Products include:
- Restylane®
- Restylane® Refyne & Defyne
- Restylane® Contour
- Restylane® Kysse
- Restylane® Lyft
- Restylane® Silk
Restylane Defyne is often a popular choice for deep wrinkles in the lower face, as it provides added support and firmness while preserving natural facial movement in the treatment area.
RHA® dermal fillers are also a good option for deep wrinkles, particularly around the nose and mouth. These products are uniquely formulated to fill in lines while preserving the natural movement of the face. They are the only fillers that can replace neuromodulators for dynamic wrinkles around the forehead and eyes.
Biostimulatory agents like Sculptra and Radiesse stimulate the body to increase collagen and elastic fiber production, plumping and smoothing the skin at a cellular level. The injectable treatments take longer to produce the desired effect, but once results are apparent, they can last up to 2 years.

Laser Options
Very deep facial wrinkles can also be addressed with various laser treatments. Fractional laser skin resurfacing creates micro-injuries in the skin, triggering the body’s natural regenerative processes and boosting collagen production. Ablative lasers remove precise layers of skin, revealing softer, smoother skin below. We offer more than 60 laser and energy devices, enabling us to customize treatments with the precision necessary to achieve the best possible results for our patients.
Another non-invasive treatment option is Thermage FLX skin tightening, which uses radiofrequency energy to stimulate collagen production, smooth fine lines, and tighten sagging skin, with no downtime.


Fraxel, Active/Deep FX, Sciton – Take10
Fraxel Re:pair is effective for treating deep wrinkles, hyperpigmentation, and scarring. This fractional laser produces dramatic results with about 7-10 days of downtime. Improvements can be quite noticeable and long-lasting.
Active/Deep FX is a combination of 2 lasers that offer fractional CO2 resurfacing to treat deep wrinkles. This treatment stimulates collagen production for natural, long-lasting results. Recovery time tends to be quicker, and improvements continue in the weeks and months after treatment.
Sciton Er:YAG Laser is a versatile device that is highly effective in skin resurfacing. The laser removes very precise layers of dermal tissue, rejuvenating the skin without scarring. The treatment depth can be adjusted from shallow to remove early lines of sun damage to deeper treatments that work on even the most severe facial creases.
Take10 is our proprietary laser treatment available only at Cosmetic Laser Dermatology. Using a combination of three or more lasers, we can improve a patient’s appearance by up to 10 years without surgery. We can also combine this treatment with injectable neuromodulators and dermal fillers to further enhance results.
What to Expect During and After Your Treatment in San Diego, CA
At Cosmetic Laser Dermatology, all of our injectable and laser treatments are performed by one of our 7 board-certified dermatologists. With over 125 years of combined experience, patients can rest assured they are in the best possible hands when they book a treatment with us.
If you are unhappy with deep wrinkles, help is available. Contact our San Diego office today to discover the best deep wrinkle treatment for you.
For more information on how different treatment options compare for deep wrinkle treatment, check out this study from the National Institute of Health.