How to Restore Collagen for Youthful, Radiant Skin
Collagen is the foundation of firm, youthful skin. As we age, our natural production of collagen, elastin, and hyaluronic acid declines, leading to fine lines, wrinkles, and loss of elasticity. Fortunately, advanced dermatological treatments can stimulate collagen regeneration, improve skin texture, and restore a youthful glow.
Top Dermatologist-Recommended Collagen Treatments
Below, our board-certified dermatologists at Cosmetic Laser Dermatology outline the best in-office collagen-boosting treatments for firmer, healthier skin.
1. Accure Laser – Best for Acne-Prone Skin
The Accure Laser is an advanced treatment originally designed for acne. It targets sebaceous glands while heating deep layers of skin to boost collagen production, refine pores, and improve texture.
✔ Results: Clearer skin, refined texture over several weeks
✔ Downtime: Minimal (mild redness or swelling)
✔ Best for: Acne-prone individuals seeking smoother, firmer skin
Learn more about Accure Laser for acne and skin rejuvenation.

2. ActiveFX & DeepFX – Best for Wrinkle Reduction

These fractional CO2 laser treatments create controlled micro-injuries in the skin, stimulating deep collagen remodeling and skin renewal.
✔ Results: Smoother, firmer skin with fewer fine lines and wrinkles
✔ Downtime: Moderate (redness, peeling for a few days)
✔ Best for: Patients seeking advanced anti-aging treatments
Explore our CO2 laser skin resurfacing options.
3. Affirm Multiplex – Best for Pigmentation & Texture
Using dual wavelengths, the Affirm Multiplex laser targets different skin layers to stimulate collagen, elastin, and hyaluronic acid growth, while reducing pigmentation and improving texture.
✔ Results: Gradual improvement in skin smoothness and firmness
✔ Downtime: Minimal (mild redness and swelling)
✔ Best for: Those looking for mild to moderate skin rejuvenation
Discover how Affirm Multiplex improves pigmentation and skin tone.

4. Clear & Brilliant – Best for Preventative Anti-Aging

The Clear & Brilliant laser is a gentle fractional laser that creates thousands of microscopic treatment zones, stimulating collagen production while improving skin tone and elasticity.
✔ Results: Brighter, firmer skin with minimal downtime
✔ Downtime: 1-2 days (redness, mild sensitivity)
✔ Best for: Those looking for a preventative anti-aging solution
Find out why Clear & Brilliant is the go-to laser for youthful skin.
5. Fraxel Dual / Repair / Restore – Best for Sun Damage & Scarring
The Fraxel Laser uses microscopic laser columns to penetrate deep into the skin, improving wrinkles, sun damage, and acne scars while stimulating long-term collagen growth.
✔ Results: Reduction in wrinkles, hyperpigmentation, and scarring
✔ Downtime: Varies (minimal for Dual/Restore, moderate for Repair)
✔ Best for: Those looking for customizable laser treatments
Discover how Fraxel laser therapy can transform your skin.

6. Potenza RF Microneedling – Best for Skin Tightening

Potenza combines microneedling with radiofrequency energy, delivering controlled heat into deeper skin layers to boost collagen, tighten skin, and refine texture.
✔ Results: Gradual improvement in firmness, elasticity, and texture
✔ Downtime: Mild (redness, slight swelling for a few days)
✔ Best for: Patients looking for non-surgical skin tightening
Learn how RF Microneedling stimulates collagen and lifts sagging skin.
7. ResurFX – Best for Skin Renewal
ResurFX is a non-ablative fractional laser that enhances collagen remodeling while improving skin texture and elasticity with minimal discomfort and downtime.
✔ Results: Gradual skin tightening and texture refinement
✔ Downtime: Minimal (some redness and mild swelling)
✔ Best for: Patients seeking gentle yet effective skin renewal
Explore how ResurFX renews and revitalizes skin.

8. Sciton Profile – Best for Custom Laser Resurfacing

This advanced laser system offers erbium and fractional laser treatments to resurface skin, improve tone, and encourage collagen remodeling.
✔ Results: Smoother, firmer skin with reduced imperfections
✔ Downtime: Varies depending on the specific laser treatment
✔ Best for: Individuals looking for customizable laser treatments
Learn more about Sciton Profile laser resurfacing.
9. UltraClear – Best for Non-Invasive Collagen Boost
UltraClear is a fractional laser treatment designed to promote collagen, hyaluronic acid, and elastin fiber regeneration.
✔ Results: Brighter, firmer, and healthier skin
✔ Downtime: Minimal (some redness and sensitivity)
✔ Best for: Patients looking for a non-invasive collagen boost
Discover how UltraClear laser enhances skin quality.

10. UltraPulse CO2 Laser – Best for Deep Wrinkle Reduction

The UltraPulse CO2 laser penetrates deep into the skin to resurface damaged tissue and stimulate long-term collagen production.
✔ Results: Significant reduction in wrinkles, scars, and texture irregularities
✔ Downtime: Moderate to significant, depending on intensity
✔ Best for: Individuals seeking dramatic skin rejuvenation
Learn more about UltraPulse CO2 laser for deep wrinkle reduction.
How Collagen-Stimulating Treatments Work
Scientific research has shown that laser therapy, microneedling, and radiofrequency treatments effectively stimulate collagen production, improve skin elasticity, and reduce signs of aging. Studies indicate that fractional lasers and RF microneedling trigger neocollagenesis—the process of new collagen formation—leading to long-term skin rejuvenation and improved texture.
For more scientific insights on collagen stimulation and dermatology treatments, explore the National Center for Biotechnology Information (NCBI) database.
Which Collagen Treatment Is Right for You?
With so many innovative options available, choosing the right treatment depends on your skin type, goals, and downtime preference. At Cosmetic Laser Dermatology, our 7 board-certified dermatologists specialize in customized, results-driven skin treatments.
Want expert guidance? Book a consultation today and get a personalized skincare plan!
Still have questions? Speak to a skincare expert at (858) 657-1002.