At our San Diego cosmetic dermatology office, our doctors are well-experienced with PhotoDynamic Therapy (PDT) treatments.

Laser treatments San DiegoPDT is a non-invasive procedure used to treat a variety of skin conditions. It is a special treatment performed with a topical photosensitizing agent called Levulan (5-aminolevulinic acid or ALA) or Metvixia (methyl aminolevulinate) which is activated with the correct wavelength of light. This treatment is also commonly referred to as “ALA or PDT treatment”, Levulan photofacial or Photodynamic Acne Therapy.

What does PDT treat?

PhotoDynamic Therapy (PDT) delivers amazing results and can treat the following conditions with minimal downtime and risk.

  • Reduce acne
  • Reduce rosacea
  • Reduce sebaceous gland hyperplasia
  • Reduce or eliminates use of oral antibiotics
  • Eliminate concerns of antibiotic-resistant bacteria
  • Sun damage
  • Pre-cancerous lesions (actinic keratosis)

photodynamic therapy dermatology

How does PDT work?

PhotoDynamic therapy in San Diego (PDT) is for the treatment of acne and other skin diseases involves the use of photochemical reactions to photosensitizing agents, light, and oxygen. PDT involves three steps. First, microdermabrasion is done and followed by the photo-sensitizer which is applied to the skin surface and taken up by the acne lesions. Then 4 specific wavelengths of lasers ( PDL, IPL, Blue Light and Red Light) are applied toward the acne lesions, activating the photo-sensitizer in the presence of oxygen.

Because the photo-sensitizer is preferentially absorbed by the acne lesions and the light source is directly targeted on the lesional tissue, PDT achieves dual selectivity, minimizing damage to adjacent healthy structures. PDT is mediated by oxygen-dependent photochemical reactions, resulting in destruction of the acne lesion.

The purpose of lasers in PDT is to initiate photochemical reactions, and not to heat or mechanically change tissue as seen in other dermatologic uses.

Photodynamic Therapy Frequently Asked Questions

What is photodynamic therapy?photodynamic therapy PDT

PDT is used to treat sun damage, pre-cancerous regions on the skin (actinic keratosis), acne and rosacea. It is performed by placing the topical photosensitizing agent Levulan on the treatment area, which is activated with a specific wavelength of light. This treatment corrects the damaged skin.


Who is a good candidate for Photodynamic Therapy in San Diego?

Patients with the following conditions are good candidates for PDT treatments:

  • Sun damaged skin
  • Actinic keratosis
  • Rosacea
  • Acne

Dr. Goldman & Dr. Groff Discuss PDT Benefits

A Happy Patient of Dr. Fabi’s Discusses Her Treatment

How many PDT treatments will I need?PDT Before and After

Many patients need multiple PDT treatments, but the number of treatments depends on what problem you are trying to correct. In many cases, patients will have 4-6 treatments. During a consultation with one of our expert San Diego cosmetic dermatologists, we will assess your needs and determine how many treatments you will need.

How does PDT work for precancerous lesions?

PDT kills cancer cells by combining a light sensitive drug with light from a laser. The treatment allows our doctors to target and destroy cancer cells without damaging the surrounding healthy skin.

What are the advantages of PDT for treating skin pre-cancer?

The benefit of PDT for treating skin pre-cancerous lesions is its ability to target specific areas. PDT also decreases the risk of skin discoloration that is often caused by routine freezing with liquid nitrogen. Additionally, there is minimal downtown after a PDT treatment.

How much downtime should I expect after a PDT treatment?

Most patients experience minimal downtime after photodynamic therapy treatments. You should avoid direct exposure to the sun fro 1-2 days after PDT, but can return to your daily activities the same day as your treatment.

What are the side effects of PDT?

PDT side effects are minimal. Some patients experience redness immediately after the treatment, but it will go away within a day or two. However, as with all laser procedures side effects can include swelling, inflimmation, redness and tenderness around the treatment area.

How much does PDT cost?

The cost of PDT varies from patient to patient depending on the goals of the treatment. To find out how much your PDT treatment will cost, schedule a consultation with one of our dermatologists.

What is levulan?

Levulan is a photosensitizing substance that has been approved by the FDA for the treatment of actinic keratosis. Levulan is activated by light to treat skin pre-cancers, sun damage, acne and rosacea.

Please contact Cosmetic Laser Dermatology at 858.657.1002 for more information on photodynamic therapy and to schedule a consultation. We are located in the UTC area of San Diego, minutes from La Jolla, Del Mar, and Downtown San Diego.